Biological variation of serum neurofilament light chain
نویسندگان
چکیده
منابع مشابه
Neurofilament light chain
Objective: To test blood and CSF neurofilament light chain (NfL) levels in relation to disease progression and survival in amyotrophic lateral sclerosis (ALS). Methods: Using an electrochemiluminescence immunoassay, NfL levels were measured in samples from 2 cohorts of patients with sporadic ALS and healthy controls, recruited in London (ALS/control, plasma: n 5 103/42) and Oxford (ALS/control,...
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MS is a chronic disease of the CNS, well recognized for its diverse clinical presentations and outcomes. Clinicians continue to struggle to predict shortor long-term prognosis of persons affected by MS, to predict response to the growing array of diseasemodifying treatments available, and to identify persons at risk of serious adverse events from those treatments. As such, valid, reliable, and ...
متن کاملSerum neurofilament light in familial Alzheimer disease
OBJECTIVES To investigate whether serum neurofilament light (NfL) concentration is increased in familial Alzheimer disease (FAD), both pre and post symptom onset, and whether it is associated with markers of disease stage and severity. METHODS We recruited 48 individuals from families with PSEN1 or APP mutations to a cross-sectional study: 18 had symptomatic Alzheimer disease (AD) and 30 were...
متن کاملNeurofilament light chain gene polymorphism and risk of multiple sclerosis in Iranian patients
Background: Multiple sclerosis (MS) is a chronic disease characterized by inflammation and degeneration of the central nervous system (CNS). High levels of Neurofilament light chain (NFL) and Neurofilament heavy chain (NFH) in cerebrospinal fluid (CSF) have been associated with a wide range of neurological diseases including MS. Subjects and methods: Peripheral blood samples were collected from...
متن کاملSerum neurofilament light chain protein is a measure of disease intensity in frontotemporal dementia
OBJECTIVE To investigate serum neurofilament light chain (NfL) concentrations in frontotemporal dementia (FTD) and to see whether they are associated with the severity of disease. METHODS Serum samples were collected from 74 participants (34 with behavioral variant FTD [bvFTD], 3 with FTD and motor neuron disease and 37 with primary progressive aphasia [PPA]) and 28 healthy controls. Twenty-f...
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ژورنال
عنوان ژورنال: Clinical Chemistry and Laboratory Medicine (CCLM)
سال: 2021
ISSN: 1437-4331,1434-6621
DOI: 10.1515/cclm-2020-1276